Intracellular pH controls WNT downstream of glycolysis in amniote embryos.

ABSTRACT: Formation of the body of vertebrate embryos proceeds sequentially by posterior addition of tissues from the tail bud. Cells of the tail bud and the posterior presomitic mesoderm, which control posterior elongation¹, exhibit a high level of aerobic glycolysis that is reminiscent of the metabolic status of cancer cells experiencing the Warburg effect^2,3. Glycolytic activity downstream of fibroblast growth factor controls WNT signalling in the tail bud³. In the neuromesodermal precursors of the tail bud⁴, WNT signalling promotes the mesodermal fate that is required for sustained axial elongation, at the expense of the neural fate^3,5. How glycolysis regulates WNT signalling in the tail bud is currently unknown. Here we used chicken embryos

SUBMITTER: Oginuma M 

PROVIDER: S-EPMC8278564 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature