Setting the Pick: Can PI3K Inhibitors Circumvent CDK4/6 Inhibitor Resistance?
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ABSTRACT:
SUBMITTER: Clark AS
PROVIDER: S-EPMC8278622 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Publications
Setting the Pick: Can PI3K Inhibitors Circumvent CDK4/6 Inhibitor Resistance?
Clark Amy S AS Makhlin Igor I DeMichele Angela A
Clinical cancer research : an official journal of the American Association for Cancer Research 20201103 2
PI3K and CDK4/6 inhibitors (CDK4/6i) are targeted therapies approved to treat advanced breast cancer; CDK4/6is are more widely used. Here, we discuss trials that examine PI3K inhibitors with novel drug combinations, including a CDK4/6i, given data implicating the pathway in CDK 4/6 resistance.<i>See related articles by Lu et al., p. 408, and Tolaney et al., p. 418</i>. ...[more]
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