Bone mesenchymal stem cells stimulation by magnetic nanoparticles and a static magnetic field: release of exosomal miR-1260a improves osteogenesis and angiogenesis.

ABSTRACT:

Background

The therapeutic potential of exosomes derived from stem cells has attracted increasing interest recently, because they can exert similar paracrine functions of stem cells and overcome the limitations of stem cells transplantation. Exosomes derived from bone mesenchymal stem cells (BMSC-Exos) have been confirmed to promote osteogenesis and angiogenesis. The magnetic nanoparticles (eg. Fe₃O₄, γ-Fe₂O₃) combined with a static magnetic field (SMF) has been commonly used to increase wound healing and bone regeneration. Hence, this study aims to evaluate whether exosomes derived from BMSCs preconditioned with a low dose of Fe₃O₄ nanoparticles with or without the SMF, exert superior pro-osteogenic and pro-angiogen

SUBMITTER: Wu D 

PROVIDER: S-EPMC8278669 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature