Molecular mechanism study of HGF/c-MET pathway activation and immune regulation for a tumor diagnosis model.

ABSTRACT:

Background

Hepatocyte growth factor (HGF) binds to the c-mesenchymal-epithelial transition (C-MET) receptor and activates downstream signaling pathways, playing an essential role in the development of various cancers. Given the role of this signaling pathway, the primary therapeutic direction focuses on identifying and designing HGF inhibitors, antagonists and other molecules to block the binding of HGF to C-MET, thereby limiting the abnormal state of other downstream genes.

Methods

This study focuses on the analysis of immune-related genes and corresponding immune functions that are significantly associated with the HGF/c-MET pathway using transcriptome data from 11 solid tumors.

Results

We systematically analyzed 11 different cancers, including expression correlatio

SUBMITTER: Shen Z 

PROVIDER: S-EPMC8278741 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature