Immunity against seasonal human coronavirus OC43 mitigates fatal deterioration of COVID-19.

ABSTRACT:

Background

The effects of high-intensity immunity on coronavirus disease 2019 (COVID-19) remain unclear. Antibodies against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) are preferentially induced in inpatients with COVID-19 compared with outpatients with milder disease, and immunosuppression is the standard therapy for severe cases. This study investigated the relationship between cross-reactive antibody production against seasonal human coronavirus and the clinical course of COVID-19.

Methods

Among the immunogenic epitopes of SARS-CoV-2, conserved peptides in human coronavirus OC43 were searched and synthesized. Enzyme-linked immunosorbent assay was designed to detect antibodies against synthesized peptides. Antibody titres against S2' cleavage site epitopes

SUBMITTER: Yamaguchi T 

PROVIDER: S-EPMC8278827 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature