Lymphocyte-Related Immunological Indicators for Stratifying Mycobacterium tuberculosis Infection.

ABSTRACT:

Background

Easily accessible tools that reliably stratify Mycobacterium tuberculosis (MTB) infection are needed to facilitate the improvement of clinical management. The current study attempts to reveal lymphocyte-related immune characteristics of active tuberculosis (ATB) patients and establish immunodiagnostic model for discriminating ATB from latent tuberculosis infection (LTBI) and healthy controls (HC).

Methods

A total of 171 subjects consisted of 54 ATB, 57 LTBI, and 60 HC were consecutively recruited at Tongji hospital from January 2019 to January 2021. All participants were tested for lymphocyte subsets, phenotype, and function. Other examination including T-SPOT and microbiological detection for MTB were performed simultaneously.

Results

Compared with

SUBMITTER: Luo Y 

PROVIDER: S-EPMC8278865 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature