Osmium(ii) tethered half-sandwich complexes: pH-dependent aqueous speciation and transfer hydrogenation in cells.

ABSTRACT: Aquation is often acknowledged as a necessary step for metallodrug activity inside the cell. Hemilabile ligands can be used for reversible metallodrug activation. We report a new family of osmium(ii) arene complexes of formula [Os(η⁶-C₆H₅(CH₂)₃OH)(XY)Cl]^+/0 (1-13) bearing the hemilabile η⁶-bound arene 3-phenylpropanol, where XY is a neutral N,N or an anionic N,O^- bidentate chelating ligand. Os-Cl bond cleavage in water leads to the formation of the hydroxido/aqua adduct, Os-OH(H). In spite of being considered inert, the hydroxido adduct unexpectedly triggers rapid tether ring formation by attachment of the pendant alcohol-oxygen to the osmium centre, resulting in the alkoxy tethered complex [Os(η

SUBMITTER: Infante-Tadeo S 

PROVIDER: S-EPMC8278929 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature