Accessing lanthanide-based, in situ illuminated optical turn-on probes by modulation of the antenna triplet state energy.

ABSTRACT: Luminescent lanthanides possess ideal properties for biological imaging, including long luminescent lifetimes and emission within the optical window. Here, we report a novel approach to responsive luminescent Tb(iii) probes that involves direct modulation of the antenna excited triplet state energy. If the triplet energy lies too close to the ⁵D₄ Tb(iii) excited state (20 500 cm^-1), energy transfer to ⁵D₄ competes with back energy transfer processes and limits lanthanide-based emission. To validate this approach, a series of pyridyl-functionalized, macrocyclic lanthanide complexes were designed, and the corresponding lowest energy triplet states were calculated using density functional theory (DFT). Subsequently, three novel constructs

SUBMITTER: Cosby AG 

PROVIDER: S-EPMC8278976 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature