Associations between statins and adverse events in primary prevention of cardiovascular disease: systematic review with pairwise, network, and dose-response meta-analyses.

ABSTRACT:

Objective

To assess the associations between statins and adverse events in primary prevention of cardiovascular disease and to examine how the associations vary by type and dosage of statins.

Design

Systematic review and meta-analysis.

Data sources

Studies were identified from previous systematic reviews and searched in Medline, Embase, and the Cochrane Central Register of Controlled Trials, up to August 2020.

Review methods

Randomised controlled trials in adults without a history of cardiovascular disease that compared statins with non-statin controls or compared different types or dosages of statins were included.

Main outcome measures

Primary outcomes were common adverse events: self-reported muscle symptoms, clinically confirmed muscle disorders, liv

SUBMITTER: Cai T 

PROVIDER: S-EPMC8279037 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature