IntraOmmaya compartmental radioimmunotherapy using ¹³¹I-omburtamab-pharmacokinetic modeling to optimize therapeutic index.

ABSTRACT:

Purpose

Radioimmunotherapy (RIT) delivered through the cerebrospinal fluid (CSF) has been shown to be a safe and promising treatment for leptomeningeal metastases. Pharmacokinetic models for intraOmmaya antiGD2 monoclonal antibody ¹³¹I-3F8 have been proposed to improve therapeutic effect while minimizing radiation toxicity. In this study, we now apply pharmacokinetic modeling to intraOmmaya ¹³¹I-omburtamab (8H9), an antiB7-H3 antibody which has shown promise in RIT of leptomeningeal metastases.

Methods

Serial CSF samples were collected and radioassayed from 61 patients undergoing a total of 177 intraOmmaya administrations of ¹³¹I-omburtamab for leptomeningeal malignancy. A two-compartment pharmacokinetic model with 12 differential equations w

SUBMITTER: Yerrabelli RS 

PROVIDER: S-EPMC8279045 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature