Reduced-dose craniospinal irradiation for central nervous system relapsed neuroblastoma.

ABSTRACT:

Purpose

In patients with high-risk neuroblastoma, there is an increased recognition of relapse in the central nervous system (CNS). Craniospinal irradiation (CSI) has been an effective treatment but carries significant long-term complications. It is unclear whether reducing the CSI dose from 21 to 18 Gy can achieve similar CNS tumor control.

Patients and methods

A retrospective review of pediatric patients with CNS-relapsed neuroblastoma treated with CSI and boost to parenchymal lesions between 2003 and 2019 was performed. The goal was to assess CNS control comparing 18 Gy and 21 Gy regimens.

Results

Ninety-four patients with CNS-relapsed neuroblastoma were treated with CSI followed by intraventricular compartmental radioimmunotherapy. Median age at the time of CNS di

SUBMITTER: Luo LY 

PROVIDER: S-EPMC8279229 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature