Characteristics and Prognosis of De Novo Hepatocellular Carcinoma After Sustained Virologic Response.

ABSTRACT: Hepatocellular carcinoma (HCC) can de novo develop in patients with chronic hepatitis C even after the achievement of sustained virologic response (SVR). We characterized de novo HCC after SVR, comparing it with HCC that developed in patients during persistent hepatitis C virus (HCV) infection. Characteristics, survival rates, and recurrence rates after curative treatment in 178 patients who developed initial HCC after SVR diagnosed between 2014 and 2020 were compared with those of 127 patients with initial HCC that developed during persistent HCV infection diagnosed between 2011 and 2015; HCC was detected under surveillance in both groups. HCC was less advanced and liver function worsened less in patients with SVR than in patients with persistent HCV. The survival rate after

SUBMITTER: Toyoda H 

PROVIDER: S-EPMC8279467 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature