SUMO-Modification of Human Nrf2 at K¹¹⁰ and K⁵³³ Regulates Its Nucleocytoplasmic Localization, Stability and Transcriptional Activity.

ABSTRACT:

Background/aims

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that binds to the antioxidant response element(s) (ARE) in target gene promoters, enabling oxidatively stressed cells to respond in order to restore redox homeostasis. Post-translational modifications (PTMs) that mediate activation of Nrf2, in the cytosol and its release from Keap1, have been extensively studied but PTMs that impact its biology after activation are beginning to emerge. In this regard, PTMs like acetylation, phosphorylation, ubiquitination and sumoylation contribute towards the Nrf2 subcellular localization, and its transactivation function. We previously demonstrated that Nrf2 traffics to the promyelocytic leukemia-nuclear bodies (PML-NB), where it is a target for modificat

SUBMITTER: Walters TS 

PROVIDER: S-EPMC8279473 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature