Systematic Review of Studies on Telomere Length in Patients with Multiple Sclerosis.

ABSTRACT: Telomeres are protective cap structures at the end of chromosomes that are essential for maintaining genomic stability. Accelerated telomere shortening is related to premature cellular senescence. Shortened telomere lengths (TL) have been implicated in the pathogenesis of various chronic immune-mediated and neurological diseases. We aimed to systematically review the current literature on the association of TL as a measure of biological age and multiple sclerosis (MS). A comprehensive literature search was conducted to identify original studies that presented data on TL in samples from persons with MS. Quantitative and qualitative information was extracted from the articles to summarize and compare the studies. A total of 51 articles were screened, and 7 of them were included in this revie

SUBMITTER: Buhring J 

PROVIDER: S-EPMC8279528 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature