Location of Subcortical Microbleeds and Recovery of Consciousness After Severe Traumatic Brain Injury.

ABSTRACT:

Background

In patients with severe traumatic brain injury (TBI), coma is associated with impaired subcortical arousal mechanisms. However, it is unknown which nuclei involved in arousal (arousal nuclei) are implicated in coma pathogenesis and are compatible with coma recovery.

Methods

We mapped an atlas of arousal nuclei in the brainstem, thalamus, hypothalamus, and basal forebrain onto 3 tesla susceptibility-weighted images (SWI) in 12 patients with acute severe TBI who presented in coma and recovered consciousness within 6 months. We assessed the spatial distribution and volume of SWI microbleeds and evaluated the association of microbleed volume with the duration of unresponsiveness and functional recovery at 6 months.

Results

There was no single arousal nucleus af

SUBMITTER: Bianciardi M 

PROVIDER: S-EPMC8279563 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature