Large Mitochondrial DNA Deletions in HIV Sensory Neuropathy.

ABSTRACT:

Objective

The primary objective of this study was to evaluate the correlation of large mitochondrial DNA (mtDNA) deletions in skin samples of people with HIV (PWH) with measures of neuropathy and prior exposure to therapy. We hypothesized that deletions would be associated with neuropathy. As secondary objectives, we determined the correlation of deletion burden with demographic data and neuropathy measures.

Methods

In this retrospective cohort study, we measured the accumulation of large mtDNA deletions in skin biopsies from PWH recruited as part of the AIDS Clinical Trials Group (ACTG). Our cohort includes individuals with and without sensory neuropathy, as well as individuals with normal or abnormal skin biopsies. Skin biopsies, sural and peroneal nerve conduction studies

SUBMITTER: Roda RH 

PROVIDER: S-EPMC8279564 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature