Effect of metformin on the high-density lipoprotein proteome in youth with type 1 diabetes.

ABSTRACT:

Background

Youth with type 1 diabetes (T1D) have normal or elevated High-Density Lipoprotein Cholesterol (HDL-C), however, the function of HDL, partly mediated by the HDL proteome, may be impaired. Metformin can be used as an adjunct therapy in youth with T1D, but its effects on the HDL proteome are unknown.

Objective

To determine the effect of metformin on the HDL proteome.

Subjects

Youth (12-20 years old) with T1D who had a BMI > 90th percentile, HbA1c > 8.0% and Tanner stage 5.

Methods

Double-blinded, placebo-controlled randomized sub-study. We examined the effects of metformin (n = 25) or placebo (n = 10) after 6 months on HDL proteome. Changes in HDL proteins were measured by data-independent acquisition (DIA) mass spectrometry and compared b

SUBMITTER: Gourgari E 

PROVIDER: S-EPMC8279605 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature