The AGE receptor, OST48 drives podocyte foot process effacement and basement membrane expansion (alters structural composition).

ABSTRACT:

Aims

The accumulation of advanced glycation end products is implicated in the development and progression of diabetic kidney disease. No study has examined whether stimulating advanced glycation clearance via receptor manipulation is reno-protective in diabetes. Podocytes, which are early contributors to diabetic kidney disease and could be a target for reno-protection.

Materials and methods

To examine the effects of increased podocyte oligosaccharyltransferase-48 on kidney function, glomerular sclerosis, tubulointerstitial fibrosis and proteome (PXD011434), we generated a mouse with increased oligosaccharyltransferase-48kDa subunit abundance in podocytes driven by the podocin promoter.

Results

Despite increased urinary clearance of advanced glycation end products, we

SUBMITTER: Zhuang A 

PROVIDER: S-EPMC8279619 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature