Re-evaluating the prevalence and factors characteristic of catecholamine secreting head and neck paragangliomas.

ABSTRACT:

Introduction

We sought to characterize the prevalence and factors characteristic of head and neck paragangliomas (HNPGLs) that secrete catecholamines to inform best practices for diagnosis and management.

Methods

This was a retrospective cohort study from 2000 to 2020 at a single-institution tertiary centre. One-hundred fifty-two patients (182 tumours) with HNPGLs with at least one measurement of urine or plasma catecholamines and/or catecholamine metabolite levels prior to treatment were included. We differentiated and characterized those patients with increased level(s) of any nature and those with 'clinically significant' versus 'clinically insignificant' catecholamine production.

Results

Thirty-one (20.4%) patients had increased catecholamine and/or catecholamine

SUBMITTER: Smith JD 

PROVIDER: S-EPMC8279627 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature