Dysregulation of Key Proteinases in Aspergillus fumigatus Induced by Blood Platelets.

ABSTRACT:

Background

Aspergillus fumigatus is the most common species causing invasive aspergillosis (IA), a life-threatening infection with more than 80% mortality. Interactions between A. fumigatus and human blood platelets lead to intravascular thrombosis and localized infarcts. To better understand A. fumigatus pathogenesis, we aimed to analyze the genetic basis of interactions between the pathogen and blood platelets.

Methods

A bioinformatic pipeline on microarray gene expression dataset, including analysis of differentially expressed genes (DEGs) using Limma R package and their molecular function, as well as biological pathways identification, was conducted to find the effective genes involved in IA. In the wet phase, the gene expression patterns following f

SUBMITTER: Arghavan B 

PROVIDER: S-EPMC8279719 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature