Cxcl17^-/- mice develop exacerbated disease in a T cell-dependent autoimmune model.

ABSTRACT: CXCL17 is a homeostatic chemokine in the mucosa known to chemoattract dendritic cells and macrophages but can also be expressed elsewhere under inflammatory conditions. Cxcl17^-/- mice have lower numbers of macrophages or dendritic cells in mucosal tissues. CXCL17 is also able to chemoattract suppressor myeloid cells that can recruit regulatory T cells. To explore a possible role of Cxcl17 in T cells, we studied T cell populations from Cxcl17^-/- or wild-type (WT) littermate mice. Cxcl17^-/- mice have higher numbers of CD4⁺ and CD8⁺ T cells in spleen and lymph nodes (LNs). Upon activation, they produce higher levels of several proinflammatory cytokines and chemokines. Furthermore, a Cxcl17^-/- mouse developed exacerbated disease

SUBMITTER: Hernandez-Ruiz M 

PROVIDER: S-EPMC8279723 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature