IDOPS, a Profile HMM-Based Tool to Detect Pesticidal Sequences and Compare Their Genetic Context.

ABSTRACT: Biopesticide-based crop protection is constantly challenged by insect resistance. Thus, expansion of available biopesticides is crucial for sustainable agriculture. Although Bacillus thuringiensis is the major agent for pesticide bioprotection, the number of bacteria species synthesizing proteins with biopesticidal potential is much higher. The Bacterial Pesticidal Protein Resource Center (BPPRC) offers a database of sequences for the control of insect pests, grouped in structural classes. Here we present IDOPS, a tool that detects novel biopesticidal sequences and analyzes them within their genetic environment. The backbone of the IDOPS detection unit is a curated collection of high-quality hidden Markov models that is in accordance with the BPPRC nomenclature. IDOPS was positively

SUBMITTER: Diaz-Valerio S 

PROVIDER: S-EPMC8279765 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature