DDIWAS: High-throughput electronic health record-based screening of drug-drug interactions.

ABSTRACT:

Objective

We developed and evaluated Drug-Drug Interaction Wide Association Study (DDIWAS). This novel method detects potential drug-drug interactions (DDIs) by leveraging data from the electronic health record (EHR) allergy list.

Materials and methods

To identify potential DDIs, DDIWAS scans for drug pairs that are frequently documented together on the allergy list. Using deidentified medical records, we tested 616 drugs for potential DDIs with simvastatin (a common lipid-lowering drug) and amlodipine (a common blood-pressure lowering drug). We evaluated the performance to rediscover known DDIs using existing knowledge bases and domain expert review. To validate potential novel DDIs, we manually reviewed patient charts and searched the literature.

Results

DDIWAS repl

SUBMITTER: Wu P 

PROVIDER: S-EPMC8279788 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature