Ontology highlight
ABSTRACT:
SUBMITTER: Lleo A
PROVIDER: S-EPMC8280160 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Lleó Alberto A Zetterberg Henrik H Pegueroles Jordi J Karikari Thomas K TK Carmona-Iragui María M Ashton Nicholas J NJ Montal Victor V Barroeta Isabel I Lantero-Rodríguez Juan J Videla Laura L Altuna Miren M Benejam Bessy B Fernandez Susana S Valldeneu Silvia S Garzón Diana D Bejanin Alexandre A Iulita Maria Florencia MF Camacho Valle V Medrano-Martorell Santiago S Belbin Olivia O Clarimon Jordi J Lehmann Sylvain S Alcolea Daniel D Blesa Rafael R Blennow Kaj K Fortea Juan J
Nature communications 20210714 1
Plasma tau phosphorylated at threonine 181 (p-tau181) predicts Alzheimer's disease (AD) pathology with high accuracy in the general population. In this study, we investigated plasma p-tau181 as a biomarker of AD in individuals with Down syndrome (DS). We included 366 adults with DS (240 asymptomatic, 43 prodromal AD, 83 AD dementia) and 44 euploid cognitively normal controls. We measured plasma p-tau181 with a Single molecule array (Simoa) assay. We examined the diagnostic performance of p-tau18 ...[more]