Quantitative standardization of resident mouse behavior for studies of aggression and social defeat.

ABSTRACT: Territorial reactive aggression in mice is used to study the biology of aggression-related behavior and is also a critical component of procedures used to study mood disorders, such as chronic social defeat stress. However, quantifying mouse aggression in a systematic, representative, and easily adoptable way that allows direct comparison between cohorts within or between studies remains a challenge. Here, we propose a structural equation modeling approach to quantify aggression observed during the resident-intruder procedure. Using data for 658 sexually experienced CD-1 male mice generated by three research groups across three institutions over a 10-year period, we developed a higher-order confirmatory factor model wherein the combined contributions of latency to the first attack, number

SUBMITTER: Kwiatkowski CC 

PROVIDER: S-EPMC8280187 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature