A stochastic oscillator model simulates the entrainment of vertebrate cellular clocks by light.

ABSTRACT: The circadian clock is a cellular mechanism that synchronizes various biological processes with respect to the time of the day. While much progress has been made characterizing the molecular mechanisms underlying this clock, it is less clear how external light cues influence the dynamics of the core clock mechanism and thereby entrain it with the light-dark cycle. Zebrafish-derived cell cultures possess clocks that are directly light-entrainable, thus providing an attractive laboratory model for circadian entrainment. Here, we have developed a stochastic oscillator model of the zebrafish circadian clock, which accounts for the core clock negative feedback loop, light input, and the proliferation of single-cell oscillator noise into population-level luminescence recordings. The model accura

SUBMITTER: Kumpost V 

PROVIDER: S-EPMC8280200 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature