GIP_HUMAN[22-51] is a new proatherogenic peptide identified by native plasma peptidomics.

ABSTRACT: We recently established a new plasma peptidomic technique and comprehensively identified a large number of low-molecular weight and low-abundance native peptides using a single drop of human plasma. To discover a novel polypeptide that potently modulates the cardiovascular system, we performed a bioinformatics analysis of the large-scale identification results, sequentially synthesized the selected peptide sequences, tested their biological activities, and identified a 30-amino-acid proatherogenic peptide, GIP_HUMAN[22-51], as a potent proatherosclerotic peptide hormone. GIP_HUMAN[22-51] has a common precursor with the glucose-dependent insulinotropic polypeptide (GIP) and is located immediately N-terminal to GIP. Chronic infusion of GIP_HUMAN[22-51] into ApoE^-/- mice accelerate

SUBMITTER: Masaki T 

PROVIDER: S-EPMC8280211 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature