Basolateral amygdala CB1 receptors gate HPA axis activation and context-cocaine memory strength during reconsolidation.

ABSTRACT: Re-exposure to a cocaine-associated context triggers craving and relapse through the retrieval of salient context-drug memories. Upon retrieval, context-drug memories become labile and temporarily sensitive to modification before they are reconsolidated into long-term memory stores. The effects of systemic cannabinoid type 1 receptor (CB1R) antagonism indicate that CB1R signaling is necessary for cocaine-memory reconsolidation and associated glutamatergic plasticity in the basolateral amygdala (BLA); however, the contribution of BLA CB1R signaling to cocaine-memory reconsolidation is unknown. Here, we assessed whether intra-BLA CB1R manipulations immediately after cocaine-memory retrieval alter cocaine-memory strength indexed by subsequent drug context-induced cocaine-seeking behavior in a

SUBMITTER: Higginbotham JA 

PROVIDER: S-EPMC8280224 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature