Higher versus lower positive end-expiratory pressure in patients without acute respiratory distress syndrome: a meta-analysis of randomized controlled trials.

ABSTRACT:

Background

We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to assess the association of higher positive end-expiratory pressure (PEEP), as opposed to lower PEEP, with hospital mortality in adult intensive care unit (ICU) patients undergoing invasive mechanical ventilation for reasons other than acute respiratory distress syndrome (ARDS).

Methods

We performed an electronic search of MEDLINE, EMBASE, Scopus, Cochrane Central Register of Controlled Trials, CINAHL, and Web of Science from inception until June 16, 2021 with no language restrictions. In addition, a research-in-progress database and grey literature were searched.

Results

We identified 22 RCTs (2225 patients) comparing higher PEEP (1007 patients) with lower PEEP (991

SUBMITTER: Pettenuzzo T 

PROVIDER: S-EPMC8280384 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature