Clinical Trials in Metastatic Uveal Melanoma: Immunotherapy.

ABSTRACT:

Background

Uveal melanoma (UM) is a rare subtype of melanoma that generally has a poor prognosis once it has metastasized. Clinical trials evaluating immune checkpoint inhibitors (ICIs) in UM have demonstrated response rates lower than those seen in cutaneous melanoma. Despite lower efficacy demonstrated in initial ICI studies, there are a number of ongoing clinical trials investigating novel immunotherapy approaches in UM.

Summary

This review aims to summarize important ongoing clinical trials investigating immunotherapeutic approaches in UM and previous trials that have evaluated a number of immunologic interventions. A thorough clinical trial investigation was conducted through clinicaltrials.gov using the disease search terms "uveal melanoma" and "ocular melanoma," exclu

SUBMITTER: Orloff M 

PROVIDER: S-EPMC8280448 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature