Altered cingulate structures and the associations with social awareness deficits and CNTNAP2 gene in autism spectrum disorder.

ABSTRACT:

Backgrounds

Although evidence suggests that the activity of the anterior cingulate cortex involves social cognition, there are inconsistent findings regarding the aberrant cingulate gray matter (GM) and scanty evidence about altered cortical thickness and white matter (WM) of cingulate in individuals with autism spectrum disorder (ASD). Evidence supports the association between the genetic variants of CNTNAP2 and altered brain connectivity. This study investigated the cingulate substructure and its association with social awareness deficits and the CNTNAP2 variants in individuals with ASD and typically-developing controls (TDC).

Methods

We assessed 118 individuals with ASD and 122 TDC with MRI and clinical evaluation. The GM, WM volumes and cortical thickness of the cingulat

SUBMITTER: Chien YL 

PROVIDER: S-EPMC8280509 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature