Drug repositioning based on network-specific core genes identifies potential drugs for the treatment of autism spectrum disorder in children.

ABSTRACT: Identification of exact causative genes is important for in silico drug repositioning based on drug-gene-disease relationships. However, the complex polygenic etiology of the autism spectrum disorder (ASD) is a challenge in the identification of etiological genes. The network-based core gene identification method can effectively use the interactions between genes and accurately identify the pathogenic genes of ASD. We developed a novel network-based drug repositioning framework that contains three steps: network-specific core gene (NCG) identification, potential therapeutic drug repositioning, and candidate drug validation. First, through the analysis of transcriptome data for 178 brain tissues, gene network analysis identified 365 NCGs in 18 coexpression modules that were significa

SUBMITTER: Gao H 

PROVIDER: S-EPMC8280514 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature