Gremlin 2 suppresses differentiation of stem/progenitor cells in the human skin.

ABSTRACT:

Introduction

The skin is comprised of various kinds of cells and has three layers, the epidermis, dermis and subcutaneous adipose tissue. Stem cells in each tissue duplicate themselves and differentiate to supply new cells that function in the tissue, and thereby maintain the tissue homeostasis. In contrast, senescent cells accumulate with age and secrete senescence-associated secretory phenotype (SASP) factors that impair surrounding cells and tissues, which lowers the capacity to maintain homeostasis in each tissue. Previously, we found Gremlin 2 (GREM2) as a novel SASP factor in the skin and reported that GREM2 suppressed the differentiation of adipose-derived stromal/stem cells. In the present study, we investigated the effects of GREM2 on stem cells in the epidermis and dermis

SUBMITTER: Kawagishi-Hotta M 

PROVIDER: S-EPMC8280529 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature