Aptamers: An Emerging Tool for Diagnosis and Therapeutics in Tuberculosis.

ABSTRACT: Tuberculosis (TB) has been plaguing human civilization for centuries, and currently around one-third of the global population is affected with TB. Development of novel intervention tools for early diagnosis and therapeutics against Mycobacterium tuberculosis (M.tb) is the main thrust area in today's scenario. In this direction global efforts were made to use aptamers, the chemical antibodies as tool for TB diagnostics and therapeutics. This review describes the various aptamers introduced for targeting M.tb and highlights the need for development of novel aptamers to selectively target virulent proteins of M.tb for vaccine and anti-TB drugs. The objective of this review is to highlight the diagnostic and therapeutic application of aptamers used for tuberculosis.

SUBMITTER: Srivastava S 

PROVIDER: S-EPMC8280756 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature