Effects of Voluntary Running Wheel Exercise-Induced Extracellular Vesicles on Anxiety.

ABSTRACT: Anxiety disorders are the most frequently diagnosed psychological condition, associated with serious comorbidities including excessive fear and interference with daily life. Drugs for anxiety disorders are typically prescribed but the side effects include weight gain, nausea, and sleepiness. Exercise is an effective treatment for anxiety. Exercise induces the release of extracellular vesicles (EVs) into the circulation, which transmit signals between organs. However, the effects of exercise-induced EVs on anxiety remain poorly understood. Here, we isolated EVs from the sera of mice that were sedentary or that voluntarily exercised. We characterized the changes in the miRNA profile of serum EVs after 4 weeks of voluntary exercise. miRNA sequencing showed that 82 miRNAs (46 of which were pos

SUBMITTER: Yoon KJ 

PROVIDER: S-EPMC8280765 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature