¹⁸F-ASEM Imaging for Evaluating Atherosclerotic Plaques Linked to α7-Nicotinic Acetylcholine Receptor.

ABSTRACT:

Background

Atherosclerosis is a chronic vascular inflammatory procedure alongside with lipid efflux disorder and foam cell formation. α7-Nicotinic acetylcholine receptor (α7nAChR) is a gated-calcium transmembrane channel widely expressed in neuron and non-neuron cells, such as monocytes and macrophages, activated T cells, dendritic cells, and mast cells. ¹⁸F-ASEM is an inhibitor targeted to α7nAChR that had been successfully applied in nervous system diseases. Previous studies had highlighted that α7nAChR was related to the emergency of vulnerable atherosclerotic plaques with excess inflammation cells. Thus, ¹⁸F-ASEM could be a complementary diagnostic approach to atherosclerotic plaques.

Materials and methods

The synthesis of ASEM precursor and ¹⁸

SUBMITTER: Yang T 

PROVIDER: S-EPMC8280778 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature