Intestinal barrier dysfunction plays an integral role in arthritis pathology and can be targeted to ameliorate disease.

ABSTRACT:

Background

Evidence suggests an important role for gut-microbiota dysbiosis in the development of rheumatoid arthritis (RA). The link between changes in gut bacteria and the development of joint inflammation is missing. Here, we address whether there are changes to the gut environment and how they contribute to arthritis pathogenesis.

Methods

We analyzed changes in markers of gut permeability, damage, and inflammation in peripheral blood and serum of RA patients. Serum, intestines, and lymphoid organs isolated from K/BxN mice with spontaneous arthritis or from wild-type, genetically modified interleukin (IL)-10R^-/-or claudin-8^-/-mice with induced arthritis were analyzed by immunofluorescence/histology, ELISA, and flow cytometry.<

SUBMITTER: Matei DE 

PROVIDER: S-EPMC8280953 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature