Active role of the central amygdala in widespread mechanical sensitization in rats with facial inflammatory pain.

ABSTRACT:

Abstract

Widespread or ectopic sensitization is a hallmark symptom of chronic pain, characterized by aberrantly enhanced pain sensitivity in multiple body regions remote from the site of original injury or inflammation. The central mechanism underlying widespread sensitization remains unidentified. The central nucleus of the amygdala (also called the central amygdala, CeA) is well situated for this role because it receives nociceptive information from diverse body sites and modulates pain sensitivity in various body regions. In this study, we examined the role of the CeA in a novel model of ectopic sensitization of rats. Injection of formalin into the left upper lip resulted in latent bilateral sensitization in the hind paw lasting >13 days in male Wistar rats. Chemogenetic inhibit

SUBMITTER: Sugimoto M 

PROVIDER: S-EPMC8280967 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature