The RD2 Pathogenicity Island Modifies the Disease Potential of the Group A <i>Streptococcus</i>.

ABSTRACT: Serotype M28 isolates of the group A Streptococcus (GAS; Streptococcus pyogenes) are nonrandomly associated with cases of puerperal sepsis, a potentially life-threatening infection that can occur in women following childbirth. Previously, we discovered that the 36.3-kb RD2 pathogenicity island, which is present in serotype M28 isolates but lacking from most other isolates, promotes the ability of M28 GAS to colonize the female reproductive tract. Here, we performed a gain-of-function study in which we introduced RD2 into representative serotype M1, M49, and M59 isolates and assessed the phenotypic consequences of RD2 acquisition. All RD2-containing derivatives colonized a higher percentage of mice, and at higher CFU levels, than did the parental isolates in a mouse vaginal colonizat

SUBMITTER: Roshika R 

PROVIDER: S-EPMC8281230 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature