Distinctive Association of the Functional Connectivity of the Posterior Cingulate Cortex on Memory Performances in Early and Late Amnestic Mild Cognitive Impairment Patients.

ABSTRACT:

Background

Attempts have been made to explore the biological basis of neurodegeneration in the amnestic mild cognitive impairment (MCI) stage, subdivided by memory performance. However, few studies have evaluated the differential impact of functional connectivity (FC) on memory performances in early- and late-MCI patients.

Objective

This study aims to explore the difference in FC of the posterior cingulate cortex (PCC) among healthy controls (HC) (n = 37), early-MCI patients (n = 30), and late-MCI patients (n = 35) and to evaluate a group-memory performance interaction against the FC of PCC.

Methods

The subjects underwent resting-state functional MRI scanning and a battery of neuropsychological tests.

Results

A significant difference among

SUBMITTER: Kang DW 

PROVIDER: S-EPMC8281268 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature