Identification of Two Novel Candidate Genetic Variants Associated With the Responsiveness to Influenza Vaccination.

ABSTRACT:

Background

Annual vaccination is the most effective prevention of influenza infection. Up to now, a series of studies have demonstrated the role of genetic variants in regulating the antibody response to influenza vaccine. However, among the Chinese population, the relationship between genetic factors and the responsiveness to influenza vaccination has not been clarified through genome-wide association study (GWAS).

Method

A total of 1,968 healthy volunteers of Chinese descent were recruited and 1,582 of them were available for the subsequent two-stage analysis. In the discovery stage, according to our inclusion criteria, 123 of 1,582 subjects were selected as group 1 and received whole-genome sequencing to identify potential variants and genes. In the verification stage, 29

SUBMITTER: Wen S 

PROVIDER: S-EPMC8281270 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature