Ontology highlight
ABSTRACT:
SUBMITTER: Imm J
PROVIDER: S-EPMC8281298 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Imm Jennifer J Pishva Ehsan E Ali Muhammadd M Kerrigan Talitha L TL Jeffries Aaron A Burrage Joe J Glaab Enrico E Cope Emma L EL Jones Kimberley M KM Allen Nicholas D ND Lunnon Katie K
Frontiers in cell and developmental biology 20210701
In development, differentiation from a pluripotent state results in global epigenetic changes, although the extent to which this occurs in induced pluripotent stem cell-based neuronal models has not been extensively characterized. In the present study, induced pluripotent stem cell colonies (33Qn1 line) were differentiated and collected at four time-points, with DNA methylation assessed using the Illumina Infinium Human Methylation EPIC BeadChip array. Dynamic changes in DNA methylation occurrin ...[more]