Dataset Information

Fructan-sensitive children with irritable bowel syndrome have distinct gut microbiome signatures.

ABSTRACT:

Background

Dietary fructans may worsen gastrointestinal symptoms in children with irritable bowel syndrome (IBS).

Aim

To determine whether gut microbiome composition and function are associated with childhood IBS fructan-induced symptoms.

Methods

Faecal samples were collected from 38 children aged 7-17 years with paediatric Rome III IBS, who previously completied a double-blind, randomised, placebo-controlled crossover (fructan vs maltodextrin) trial. Fructan sensitivity was defined as an increase of ≥30% in abdominal pain frequency during the fructan diet. Gut microbial composition was determined via 16Sv4 rDNA sequencing. LEfSe evaluated taxonomic composition differences. Tax4Fun2 predicted microbial fructan metabolic pathways.