The Spectrum of C4d Deposition in Renal Biopsies of Lupus Nephritis Patients.

ABSTRACT:

Objectives

This study aimed to determine the prevalence and localization of complement factor C4d in renal biopsies from patients with lupus nephritis (LN), as well as its associations with the disease's clinico-pathological features. The correlation between arteriolar C4d deposition and renal microvascular lesions (RVLs) was further analyzed.

Methods

A total of 325 biopsy-proven LN patients were enrolled, and their clinico-pathological data were collected. C4d staining of renal biopsies was performed by immunohistochemistry. The associations between C4d deposition and the clinico-pathological features were further analyzed.

Results

C4d deposition was present in most (98.8%) renal specimens in our cohort. These deposits were localized in the glomeruli (98.2%), tubular

SUBMITTER: Ding Y 

PROVIDER: S-EPMC8281350 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature