Efferocytosis by Paneth cells within the intestine.

ABSTRACT: Apoptotic cells are quickly and efficiently engulfed and removed via the process of efferocytosis by either professional phagocytes, such as macrophages, or non-professional phagocytes, including epithelial cells.^1,2 In addition to debris removal, a key benefit of efferocytosis is that phagocytes engulfing apoptotic cells release anti-inflammatory mediators^3,4 that help reduce local tissue inflammation;⁵ conversely, accumulation of uncleared apoptotic cells predisposes to a pro-inflammatory tissue milieu.^6-8 Due to their high proliferative capacity, intestinal epithelial cells (iECs) are sensitive to inflammation, irradiation, and chemotherapy-induced DNA damage, leading to apoptosis. Mechanisms of iEC

SUBMITTER: Shankman LS 

PROVIDER: S-EPMC8281366 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature