Liver transplantation for hepatocellular carcinoma: Improving eligibility without compromising outcomes.

ABSTRACT:

Background

In the context of liver transplantation for hepatocellular carcinoma (HCC), traditional transplant criteria appear restrictive. The objective of the current study was to determine risk factors for recurrence and improve transplant eligibility in patients with HCC.

Materials and methods

This was a retrospective study of patients who underwent living donor liver transplant (LDLT) for HCC (n = 219). Largest tumor diameter, tumor number, AFP and neutrophil to lymphocyte ratio were assessed. Multivariate analysis was performed to develop risk scores. The new model was compared with seven previously published transplant criteria using receiver operator curves.

Results

Largest tumor size >3.7 cm [HR:2.6, P = 0.02], and AFP > 600 ng/ml [HR:4.7, P</

SUBMITTER: Hafeez Bhatti AB 

PROVIDER: S-EPMC8281598 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature