Mesenchymal stem cell transplantation for vaginal repair in an ovariectomized rhesus macaque model.

ABSTRACT:

Background

Current surgical therapies for pelvic organ prolapse (POP) do not repair weak vaginal tissue and just provide support; these therapies may trigger severe complications. Stem cell-based regenerative therapy, due to its ability to reconstruct damaged tissue, may be a promising therapeutic strategy for POP. The objective of this study is to evaluate whether mesenchymal stem cell (MSC) therapy can repair weak vaginal tissue in an ovariectomized rhesus macaque model.

Methods

A bilateral ovariectomy model was established in rhesus macaques to induce menopause-related vaginal injury. Ten bilaterally ovariectomized rhesus macaques were divided into two groups (n=5/group): the saline group and the MSC group. Three months after ovariectomy, saline or MSCs were injected in s

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8281669 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature