Human Beta-Defensin 2 and 3 Inhibit HIV-1 Replication in Macrophages.

ABSTRACT: Human beta-defensins (hBDs) are broad-spectrum antimicrobial peptides, secreted by epithelial cells of the skin and mucosae, and astrocytes, which we and others have shown to inhibit HIV-1 in primary CD4⁺ T cells. Although loss of CD4⁺ T cells contributes to mucosal immune dysfunction, macrophages are a major source of persistence and spread of HIV and also contribute to the development of various HIV-associated complications. We hypothesized that, besides T cells, hBDs could protect macrophages from HIV. Our data in primary human monocyte-derived macrophages (MDM) in vitro show that hBD2 and hBD3 inhibit HIV replication in a dose-dependent manner. We determined that hBD2 neither alters surface expression of HIV receptors nor induces expression of anti-HIV cyto

SUBMITTER: Bharucha JP 

PROVIDER: S-EPMC8281893 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature