The RNA-binding protein Igf2bp3 is critical for embryonic and germline development in zebrafish.

ABSTRACT: The ability to reproduce is essential in all branches of life. In metazoans, this process is initiated by formation of the germline, a group of cells that are destined to form the future gonads, the tissue that will produce the gametes. The molecular mechanisms underlying germline formation differs between species. In zebrafish, development of the germline is dependent on the specification, migration and proliferation of progenitors called the primordial germ cells (PGCs). PGC specification is dependent on a maternally provided cytoplasmic complex of ribonucleoproteins (RNPs), the germplasm. Here, we show that the conserved RNA-binding protein (RBP), Igf2bp3, has an essential role during early embryonic development and germline development. Loss of Igf2bp3 leads to an expanded yolk syncyti

SUBMITTER: Vong YH 

PROVIDER: S-EPMC8282044 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature