Sperm migration in the genital tract-In silico experiments identify key factors for reproductive success.

ABSTRACT: Sperm migration in the female genital tract controls sperm selection and, therefore, reproductive success as male gametes are conditioned for fertilization while their number is dramatically reduced. Mechanisms underlying sperm migration are mostly unknown, since in vivo investigations are mostly unfeasible for ethical or practical reasons. By presenting a spatio-temporal model of the mammalian female genital tract combined with agent-based description of sperm motion and interaction as well as parameterizing it with bovine data, we offer an alternative possibility for studying sperm migration in silico. The model incorporates genital tract geometry as well as biophysical principles of sperm motion observed in vitro such as positive rheotaxis and thigmotaxis. This model for sperm migration

SUBMITTER: Diemer J 

PROVIDER: S-EPMC8282070 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature